This is the traditional way RVs and campers have been built for decades. A wood or aluminum stud frame forms the skeleton of the camper, and exterior walls (typically laminated fiberglass or composite skins over insulation) get attached to that frame. The frame carries the primary structural loads, while the skin adds some rigidity.
The approach has real advantages, which is why it's stayed dominant. It's the most affordable way to build, so it covers the widest range of price points and floorplans, from entry-level units to premium multi-slide builds. The materials and methods are well understood, and because almost every RV shop knows how to work on framed construction, repairs and parts are easy to source just about anywhere.
Framed construction relies on sealants at the seams, so resealing is part of ownership. Frame-and-panel builds have joints where the walls meet the floor, roof, slide-outs, windows, and doors, and each one depends on caulking and sealant to keep water out. Those seals need inspection and periodic resealing, which is ongoing work and cost over the life of the camper. It's manageable and predictable, but it does need doing. Skip it, or start with a poorly built camper, and water can get in and rot wood framing, delaminate walls, or corrode aluminum framing.
Framing material matters here too. Aluminum studs conduct cold more readily than wood, acting as thermal bridges that can show up as condensation lines where the framing runs. Wood avoids that but is more vulnerable to water damage. Different tradeoffs, neither strictly better.
Build quality varies widely across framed campers. Framing material, sealant quality, and how well the seams are detailed all differ between manufacturers and make a real difference in how a camper ages. A well-built, cared-for framed camper lasts 20+ years, while a poorly built or neglected one can develop rot in under 10. Repairs are usually moderate and straightforward when you catch damage early and it's localized, but widespread water intrusion gets expensive.
Best suited to pavement and moderate dirt roads. With many fastened joints and seams, there are more points that can work loose under long-term vibration, though a well-built camper with quality fasteners holds up well.